The purpose of this study was to assess patient frailty as a risk factor for radical cystectomy (RC) complications.

We performed an analysis of prospectively collected data of consecutive patients 80 years of age or older who underwent RC and ureterocutaneostomy in 6 primary care European urology centers. Frailty was measured using a simplified frailty index (sFI) with a 5-item score including: (1) diabetes mellitus; (2) functional status; (3) chronic obstructive pulmonary disease; (4) congestive cardiac failure; and (5) hypertension, with a maximum 5-item score meaning high level of frailty. Within 90 days surgical complications were scored according to the Clavien Classification System (CCS). sFI ≥3 was considered as poor frailty status. Clinical and pathological variables were analyzed as predictors of severe complications (CCS ≥3).

One hundred seventeen patients were enrolled. Most patients reported an sFI score of 2 and 3, respectively, 31/117 (26.5%) and 45/117 patients (38.5%). CCS ≥3 occurred in 17/117 patients (14.5%). Patients with sFI ≥3 were significantly older than patients with sFI <3 (median age, 85 years [interquartile range (IQR), 82-86] versus 82 years [IQR, 80-84]; P = .001). Most CCS ≥3 scores occurred in patients with sFI ≥3: 13 (11.1%) versus 4 (3.4%; P = .02). No significative differences were detected in terms of length of hospital stay, pathological stage, and postoperative bowel canalization when related to sFI. sFI ≥3 was an independent risk factor of CCS ≥3 in univariate and multivariate analysis (respectively, odds ratio [OR], 3.81 [95% confidence interval (CI), 1.16-12.5; P = .02] and OR, 3.1 [95% CI, 0.7-13.7; P = .01]). Body mass index, age, American Society of Anesthesiologists score ≥3, and pathological stage were not related to CCS ≥3.

RC appears feasible in elderly patients with an sFI <3. In cases of sFI ≥3, this choice should be carefully valued, discussed, and possibly avoided because of a higher risk of complications.

Clinical genitourinary cancer. 2019 Jul 19 [Epub ahead of print]

Cosimo De Nunzio, Antonio Cicione, Laura Izquierdo, Riccardo Lombardo, Giorgia Tema, Giuseppe Lotrecchiano, Andrea Minervini, Giuseppe Simone, Luca Cindolo, Carlo D’Orta, Tarek Ajami, Alessandro Antonelli, Marco Della Bella, Antonio Alcaraz, Andrea Tubaro

Department of Urology, Ospedale Sant’Andrea-Università di Roma “Sapienza”, Rome, Italy. Electronic address: ., Department of Urology, Ospedale Sant’Andrea-Università di Roma “Sapienza”, Rome, Italy., Department of Urology, Hospital Clinic of Barcelona, Barcelona, Spain., Department of Urology, Ospedale Civile, Benevento, Italy., Department of Urology, Ospedale Careggi, University of Florence, Florence, Italy., Department of Urology, “Regina Elena” National Cancer Institute, Rome, Italy., Department of Urology, “S. Pio” Hospital, Vasto, Italy., Department of Urology, “Spedali Civili,” Brescia, Italy., Department of Urology, “INCRA,” Ancona, Italy.