Despite the important relationship between renorrhaphy and functional outcomes of partial nephrectomy, the urological guidelines do not provide recommendations about the optimal renorrhaphy technique. We carried out the first pooled literature analysis of the impact of suture technique on ultimate renal function after partial nephrectomy. Three studies comparing interrupted versus running suture including data on glomerular filtration rate (GFR) were included, for a total of 124 versus 269 patients. No significant differences were found between pre- and postoperative GFR in either patients who received an interrupted suture (weighted mean difference, -4.88ml/min, 95% confidence interval [CI] -11.38; 1.63, p=0.14) or those who received a running suture (-3.42ml/min, 95% CI -9.96; 3.12, p=0.31). Three studies comparing single- versus double-layer renorrhaphy included data on GFR (321 vs 199 patients). A benefit in functional outcomes favored single-layer technique (-3.19ml/min, 95% CI -8.09; 1.70, p=0.2 vs -6.07ml/min, 95% CI -10.75; -1.39, p=0.01). In conclusion, our quantitative synthesis suggests a renal functional benefit of the single-layer closure during partial nephrectomy. PATIENT SUMMARY: The available studies on renal functional data included in the present review suggest that “less is more” for renorrhaphy after partial nephrectomy. The single-layer renorrhaphy technique showed advantages in renal functional outcomes compared with the double-layer technique.

European urology oncology. 2018 Dec 09 [Epub ahead of print]

Riccardo Bertolo, Riccardo Campi, Maria Carmen Mir, Tobias Klatte, Maximilian C Kriegmair, Maciej Salagierski, Idir Ouzaid, Umberto Capitanio, Young Academic Urologists Kidney Cancer Working Group of the European Urological Association

Department of Urology, Cleveland Clinic Foundation, Cleveland, OH, USA. Electronic address: ., Department of Urology, University of Florence, Florence, Italy., Department of Urology, Fundacion Instituto Valenciano de Oncologia, Valencia, Spain., Department of Urology, Royal Bournemouth and Christchurch Hospitals NHS Trust, Bournemouth, UK; Department of Surgery, University of Cambridge, Cambridge, UK., Department of Urology, University Medical Centre Mannheim, Mannheim, Germany., The Faculty of Medicine and Health Sciences, University of Zielona Góra, Zielona Góra, Poland., Department of Urology, Bichat Hospital, APHP, Paris Diderot University, Paris, France., Department of Urology, San Raffaele Scientific Institute, Milan, Italy; Division of Experimental Oncology/Unit of Urology, URI, IRCCS San Raffaele Hospital, Milan, Italy.