The purpose of this study is to evaluate the efficacy of intra-vesical instillations with hyaluronic acid (HA) in relieving lower urinary tract irritation symptoms in patients with urinary tract infections (UTIs) and bladder pain syndrome/interstitial cystitis (BPS/IC). This research, conducted in Romania, includes 30 patients with UTIs (Group I) and 24 with BPS/IC (Group II) as defined by European Association of Urology (EAU) Diagnostic Criteria. Data were collected prospectively, using pre- and post-treatment questionnaires for pelvic pain with a symptom scale for urination and frequency as well as visual analog scale (VAS) pain quizzes. At follow-up visits, at an average of 20 months, a significant improvement in urinary bladder pain, day-time urinary frequency and quality of life was observed in Group I patients. Group II patients experienced significant improvement in urinary bladder pain, urgency, nocturia and quality of life at the 15-month follow-up visit. Eighteen patients (75%) showed a complete response to intravesical HA instillations and required no further treatment. Our study demonstrates that intravesical HA instillations may be considered as an important treatment component, with long term positive effects in therapeutic strategy for optimal results in uncomplicated recurrent UTIs and BPS/IC, with good compliance and minimal side effects.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2019 Sep 06 [Epub ahead of print]

Ioan Scarneciu, Simona Bungau, Aura-Mihaela Lupu, Camelia C Scarneciu, Ovidiu Gabriel Bratu, Orsolya Martha, Delia Mirela Tit, Lotfi Aleya, Sorin Lupu

Department of Medical and Surgical Specialities, “Transilvania” University of Brasov, Brasov, Romania., Department of Pharmacy, University of Oradea, Oradea, Romania., Department of Radiology, Brasov CF General Hospital, Brasov, Romania., Department of Fundamental, Prophylactic and Clinical Disciplines, “Transilvania” University of Brasov, Brasov, Romania., Clinical Department 3, University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania., Clinical Department of Surgery M5, University of Medicine, Pharmacy, Science and Technology of Targu Mures, Targu Mures, Romania., Laboratoire Chrono-environnement, CNRS 6249 Université de Franche-Comté, Besançon, France. Electronic address: ., Clinic of Urology, Brasov Emergency Clinical Hospital, Brasov, Romania.