To investigate the efficacy of tadalafil for patients with benign prostatic hyperplasia and chronic prostatitis/chronic pelvic pain syndrome.
Tadalafil 5 mg was given each morning for 12 weeks to patients diagnosed as having either moderate or severe lower urinary tract symptoms. Voiding symptoms were compared between patients with a high (≥4; high group) and low (<4; low group) pain subscore of the National Institutes of Health Chronic Prostatitis Symptom Index before and after tadalafil administration. The correlation between changes in the Chronic Prostatitis Symptom Index and the International Prostate Symptom Score during treatment was also investigated.
At baseline, the pain subscore of the Chronic Prostatitis Symptom Index was high (≥4) in 24 of 74 (32.4%) patients. The International Prostate Symptom Score in the group with a high pain subscore was significantly higher than that in the group with a low pain subscore. International Prostate Symptom Score, National Institutes of Health Chronic Prostatitis Symptom Index total score and pain subscore were all significantly improved after treatment. The change in the Chronic Prostatitis Symptom Index total score correlated positively with the change in the International Prostate Symptom Score. The decrease in the International Prostate Symptom Score was significantly greater in the group with high versus low pain subscore.
Tadalafil is sufficiently effective in the treatment of patients with benign prostatic hyperplasia and severe chronic prostatitis/chronic pelvic pain syndrome.
International journal of urology : official journal of the Japanese Urological Association. 2019 Oct 06 [Epub ahead of print]
Ippei Hiramatsu, Akira Tsujimura, Miho Soejima, Azusa Yoshiyama, Yuki Nagashima, Keisuke Ishikawa, Yuka Uesaka, Taiji Nozaki, Tatsuya Ogishima, Masato Shirai, Isao Mitsuhashi, Sosuke Sugimura, Taiki Mizuno, Kensho Noto, Yasuhiro Shigeta, Jiro Takasu, Shinichi Honda, Shinji Iwata, Shigeo Horie
Department of Urology, Juntendo University Graduate School of Medicine, Tokyo, Japan., Department of Urology, Juntendo University Urayasu Hospital, Urayasu, Chiba, Japan., Department of Urology, Nishi-Funabashi Urology Clinic, Funabashi, Chiba, Japan., Department of Urology, Urayasu Central Hospital, Urayasu, Chiba, Japan., Department of Urology, Yatsu Hoken Hospital, Narashino, Chiba, Japan.