(UroToday.com) Industrial byproducts and environmental pollutants are associated with the development of urothelial carcinoma. While tobacco exposure (50-65%) is the major risk factor for urothelial carcinoma, the interaction between sources of industrial byproducts and environmental pollutants and incidence of urothelial carcinoma in surrounding communities has been infrequently explored. At the American Society of Clinical Oncology Genitourinary Cancers Symposium (ASCO GU), Dr. Daniel Edwards and colleagues presented results of their study assessing socio-environmental conditions associated with geospatial clusters of urothelial carcinoma. The objectives of this study were to (i) identify geospatially-significant “hotspot” clusters of urothelial carcinoma, (ii) determine socioeconomic and clinicopathologic characteristics of patients who reside in these hotspots, and (iii) characterize the relationship between sources of industrial and environmental exposures and residing in geospatial hotspots.