(UroToday.com) Cisplatin-based neoadjuvant chemotherapy followed by radical cystectomy is a standard of care for non-metastatic muscle-invasive bladder cancer (MIBC). However, up to half of patients are not eligible for cisplatin-based chemotherapy. Neoadjuvant immune checkpoint inhibitors have shown anti-tumor activity in MIBC in multiple studies, both as monotherapy and in combination with chemotherapy. In this presentation, Dr. Nieves Martinez Chanza presented preliminary results from the AURA study, which studied the pathologic complete response rate with the addition of avelumab to neoadjuvant therapy in both cisplatin eligible and cisplatin-ineligible patients with MIBC.