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p53 immunohistochemistry has been used for decades in the evaluation of solid organ malignancies. It is widely employed in gynecologic pathology in the assessment of predominantly endometrial but also ovarian carcinomas. Both these tumor types exhibit a dual pathway model of carcinogenesis, with p53 loss or overexpression commonly seen in more aggressive cancers. p53 immunostaining […]

Bone targeted therapy with zoledronic acid or denosumab has been shown to reduce the rates of skeletal-related events when initiated at the time of castrate resistance for prostate cancer. However, when studied in the hormone-sensitive setting there was no benefit to early initiation of zoledronic acid. In the current era of effective, life-prolonging therapies in […]

Alicia Morgans: Hi, my name is Alicia Morgans. I’m a GU medical oncologist and Associate Professor of Medicine at Northwestern University in Chicago in the United States. I’m so excited to have here with me today Dr. Karim Fizazi, who is a Professor of Oncology and a GU medical oncologist at Gustave Roussy, in Paris, […]

— Trial on track to meet prespecified criteria for success on its primary endpoint, with 31% (8/26) disease control rate in evaluable patients in cohorts A and B. Patients eligible for the trial have two consecutive rises in PSA levels indicating initial resistance to abiraterone (Zytiga®) — Safety demonstrated across all three dose/dose scheduling cohorts, […]

To predict overall survival, cancer, and metastasis specific survival in upper tract urothelial carcinoma (UTUC) following radical nephroureterectomy (RNU). All nonmetastatic UTUC patients who underwent RNU with a curative intent at 1 institution between December 1998 and January 2017 were included.

Accurate prediction of the prognosis of RCC using a single biomarker is challenging due to the genetic heterogeneity of the disease. However, it is essential to develop an accurate system to allow better patient selection for optimal treatment strategies.

Vascular endothelial growth factor-directed therapies play a significant role in patients with metastatic renal cell carcinoma (mRCC). Biomarkers for predicting treatment efficacy and resistance are required to develop personalized medicine.

Metastatic renal cell carcinoma (RCC) is associated with poor prognosis. Ras protein activator like 2 (RASAL2) protein has been previously demonstrated to serves as a tumor suppressor in a variety of malignancies.

Adaptive Stereotactic Body Radiotherapy (SBRT) of prostate cancer (PC) by online 1.5 T MRi-guidance prolongs session-time, due to contouring and planning tasks, thus increasing the risk of prostate motion.

Various radiolabeled prostate-specific membrane antigen (PSMA)-targeting tracers are clinically applied for prostate cancer (PCa) imaging and targeted radionuclide therapy. The PSMA binding affinities, biodistribution, and DNA-damaging capacities of these radiotracers have not yet been compared in detail.